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Heparin Induced Thrombocytopenia will usually manifest as a thrombotic, rather than a hemorrhagic, disorder, and may occur in a patient already on prophylaxis for a thrombotic disorder because of previous exposure to heparin. It can be missed because of delay between heparin exposure and clinical presentation. Signs and symptoms often suggest another diagnosis.

The need for screening platelets and the likelihood of a diagnosis depend on pretest probability, which can be determined using a calculator available on the web or by download from the home page.

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